Depends on where the hotel is located. If you go downtown, midtown, or buckhead/lenox there are a lot of options. Unfortunately the train doesn't run everywhere conveniently so you would have to get a spot near a stop.
Taxi or uber is probably the easiest option for most. You get panhandling and whatnot on Marta, but I'm kinda used to it by now. If you are cool with public transportation and trying to do it on the cheap, it's 2.50 a trip. I just recommend ear buds to avoid the inevitable sales pitch or dance performance.
Looks like that GA TECH hotel is between 10th street and north ave. stations probably in tech square which is a nicer transitional spot. They are building a lot of new towers over on Spring street.